Hereditary Renal Cancer

Testing with GenPath Hereditary Renal Cancer Panel may be appropriate if the patient’s individual and/or family history is suggestive of a hereditary predisposition to renal (kidney) cancer. This includes:

• A personal or family history of renal cancer at a young age (i.e., ≤45 years)
• A personal or family history of bilateral renal cancer (disease in both kidneys) or multiple primary tumors in a single kidney
• Multiple renal cancers on the same side of the family
• A pattern of similar or related cancers on one side of a family, spanning multiple generations

The panel consists of 18 genes associated with an increased risk for renal and other cancers.

Genes tested for in this panel include: BAP1, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, and VHL.