OnkoSight AdvancedTM for Lung Cancer

OnkoSight AdvancedTM lung cancer panel is optimized to provide high sensitivity and specificity for low-frequency somatic variants. DNA biomarkers include single nucleotide variants (SNVs), insertions, deletions, copy number variants (CNVs), and multinucleotide variants (MNVs).

Many genomic aberrations have been identified that impact therapy selection in non-small cell lung cancer (NSCLC) – a type of lung cancer that accounts for about 80-85% of lung cancer cases. Testing for these aberrations is imperative to:

  • Identify an efficacious targeted therapy
  • Avoid therapies unlikely to provide clinical benefit

Per the National Comprehensive Cancer Network (NCCN), a broad-based next-generation sequencing (NGS) panel is recommended to identify genomic aberrations in NSCLC. For patients who, in broad panel testing don’t have identifiable driver mutations, an RNA-based NGS may be considered to maximize the detection of fusion events.

GenPath® Oncology, a division of BioReference®, prides itself on being a leading provider of cutting-edge cancer diagnostics with industry-leading turnaround times. GenPath offers comprehensive profiles for lung cancer, that includes DNA, RNA, and PD-L1 22C3 (Test code M338-2), as well as targeted DNA and RNA panels and other tests for lung cancer to assist healthcare providers in identifying targeted treatment strategies.

BIOMARKER THERAPY GENPATH® TEST OPTION
EGFR exon 19 deletions and EGFR exon 21 L858R alterations Gilotrif® (afatinib), Iressa® (gefitinib), Tarceva® (erlotinib), Vizimpro® (dacomitinib), Cyramza® (ramucirumab), Tagrisso® (osimertinib) M338-2 Comprehensive OnkoSight AdvancedTM Lung Panel
TH49-0 OnkoSight Advanced Lung Cancer Panel
EGFR exon 20 T790M alterations Tagrisso® (osimertinib)
EGFR exon 20 insertions Rybrevant® (amivantamab-vmjw)
ALK rearrangements Alecensa® (alectinib), Xalkori® (crizotinib), Zykadia® (ceritinib), Alunbrig® (brigatinib), Lorbrena® (lorlatinib)
BRAF V600E Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib)
KRAS G12C Lumakras® (sotorasib), Krazati® (adagrasib)
MET exon 14 skipping alterations Tepmetko® (tepotinib), Tabrecta® (capmatinib)
NTRK fusions Rozlytrk® (entrectinib), Vitrakvi® (larotrectinib) M338-2 Comprehensive OnkoSight Advanced Lung Panel
J355-9 Solid Tumor RNA Gene Fusion Assay
RET rearrangements or fusion-positive Gavreto® (pralsetinib), Retevmo® (selpercatinib)
ROS1 rearrangements or fusion-positive Xalkori® (crizotinib), Rozlytrek® (entrectinib)
PD-L1 Keytruda® (pembrolizumab), Nivolumab® (Opdivo), Tecentriq® (atezolizumab) B993-7 PD-L1 22C3 by IHC for Keytruda
J221-3 PD-L1 28-8 by IHC for Opdivo

Test Information

M338-2

DNA (TH49-0)
 RNA (J355-9)
 PD-L1 22C3 (B993-7)

TH49-0

AKT1
 ALK
 ATR
 BRAF
 CHEK1
 DDR2
 EGFR
 ERBB2
ERBB3
 FGFR1
HRAS
 KRAS
 MAP2K1
 MET
 NRAS
 NTRK1
 PIK3CA
 POLD1
 POLE
 ROS1
 STK11
 TERT
 TP53

J355-9

ALK
 AXL
 BRAF
 CCND1
 EGFR
 FGFR1
 FGFR2
 FGFR3
 MET
 NRG1
 NTRK1
 NTRK2
 NTRK3
 PPARG
 RAF1
 RET
 ROS1
 THADA

B993-7

J221-3

TM79-6

AKT1
 ALK
 APC
 AR
 ARAF
 BRAF
 CCND1
 CCND2
 CCND3
 CDK4
 CDK5
 CHECK2
 CTNNB1
 DDR2
 EGFR
 ERBB2
 ERBB3
 ERG
 ESR1
 ETV1
 FBXW7
 FGFR1
 FGFR2
 FGFR3
 FGFR4
 FLT3
 GNA11
 GNAQ
 GNAS
 HRAS
 IDH1
 IDH2
 KIT
 KRAS
 MAP2K1
 MAP2K2
 MET
 MTOR
 MYC
 NRAS
 NTRK1
 NTRK3
 PDGFRA
 PIK3CA
 PTEN
 RAF-1
 RET
 ROS1
 SF3B1
 SMAD4
 SMO
 TP53

Healthcare providers should only order panels if each gene or test in the panel is medically necessary.