OnkoSight AdvancedTM for Lung Cancer
OnkoSight AdvancedTM lung cancer panel is optimized to provide high sensitivity and specificity for low-frequency somatic variants. DNA biomarkers include single nucleotide variants (SNVs), insertions, deletions, copy number variants (CNVs), and multinucleotide variants (MNVs).
Many genomic aberrations have been identified that impact therapy selection in non-small cell lung cancer (NSCLC) – a type of lung cancer that accounts for about 80-85% of lung cancer cases. Testing for these aberrations is imperative to:
- Identify an efficacious targeted therapy
- Avoid therapies unlikely to provide clinical benefit
Per the National Comprehensive Cancer Network (NCCN), a broad-based next-generation sequencing (NGS) panel is recommended to identify genomic aberrations in NSCLC. For patients who, in broad panel testing don’t have identifiable driver mutations, an RNA-based NGS may be considered to maximize the detection of fusion events.
GenPath® Oncology, a division of BioReference®, prides itself on being a leading provider of cutting-edge cancer diagnostics with industry-leading turnaround times. GenPath offers comprehensive profiles for lung cancer, that includes DNA, RNA, and PD-L1 22C3 (Test code M338-2), as well as targeted DNA and RNA panels and other tests for lung cancer to assist healthcare providers in identifying targeted treatment strategies.
BIOMARKER | THERAPY | GENPATH® TEST OPTION |
EGFR exon 19 deletions and EGFR exon 21 L858R alterations | Gilotrif® (afatinib), Iressa® (gefitinib), Tarceva® (erlotinib), Vizimpro® (dacomitinib), Cyramza® (ramucirumab), Tagrisso® (osimertinib) | M338-2 Comprehensive OnkoSight AdvancedTM Lung Panel TH49-0 OnkoSight Advanced Lung Cancer Panel |
EGFR exon 20 T790M alterations | Tagrisso® (osimertinib) | |
EGFR exon 20 insertions | Rybrevant® (amivantamab-vmjw) | |
ALK rearrangements | Alecensa® (alectinib), Xalkori® (crizotinib), Zykadia® (ceritinib), Alunbrig® (brigatinib), Lorbrena® (lorlatinib) | |
BRAF V600E | Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib) | |
KRAS G12C | Lumakras® (sotorasib), Krazati® (adagrasib) | |
MET exon 14 skipping alterations | Tepmetko® (tepotinib), Tabrecta® (capmatinib) | |
NTRK fusions | Rozlytrk® (entrectinib), Vitrakvi® (larotrectinib) | M338-2 Comprehensive OnkoSight Advanced Lung Panel J355-9 Solid Tumor RNA Gene Fusion Assay |
RET rearrangements or fusion-positive | Gavreto® (pralsetinib), Retevmo® (selpercatinib) | |
ROS1 rearrangements or fusion-positive | Xalkori® (crizotinib), Rozlytrek® (entrectinib) | |
PD-L1 | Keytruda® (pembrolizumab), Nivolumab® (Opdivo), Tecentriq® (atezolizumab) | B993-7 PD-L1 22C3 by IHC for Keytruda J221-3 PD-L1 28-8 by IHC for Opdivo |
Test Information
Comprehensive OnkoSight AdvancedTM Lung Panel
M338-2
DNA (TH49-0) |
RNA (J355-9) |
PD-L1 22C3 (B993-7) |
OnkoSight Advanced Lung Cancer Panel (23 genes, TMB, and Tumor-only MSI)
TH49-0
AKT1 |
ALK |
ATR |
BRAF |
CHEK1 |
DDR2 |
EGFR |
ERBB2 |
ERBB3 |
FGFR1 |
HRAS |
KRAS |
MAP2K1 |
MET |
NRAS |
NTRK1 |
PIK3CA |
POLD1 |
POLE |
ROS1 |
STK11 |
TERT |
TP53 |
Solid Tumor RNA Gene Fusion Assay (18 genes)
J355-9
ALK |
AXL |
BRAF |
CCND1 |
EGFR |
FGFR1 |
FGFR2 |
FGFR3 |
MET |
NRG1 |
NTRK1 |
NTRK2 |
NTRK3 |
PPARG |
RAF1 |
RET |
ROS1 |
THADA |
PD-L1 22C3 by IHC for Keytruda
B993-7
PD-L1 28-8 by IHC for Opdivo
J221-3
GeneStrat NGS Liquid Biopsy Test (52 genes) - Powered by Biodesix
TM79-6
AKT1 |
ALK |
APC |
AR |
ARAF |
BRAF |
CCND1 |
CCND2 |
CCND3 |
CDK4 |
CDK5 |
CHECK2 |
CTNNB1 |
DDR2 |
EGFR |
ERBB2 |
ERBB3 |
ERG |
ESR1 |
ETV1 |
FBXW7 |
FGFR1 |
FGFR2 |
FGFR3 |
FGFR4 |
FLT3 |
GNA11 |
GNAQ |
GNAS |
HRAS |
IDH1 |
IDH2 |
KIT |
KRAS |
MAP2K1 |
MAP2K2 |
MET |
MTOR |
MYC |
NRAS |
NTRK1 |
NTRK3 |
PDGFRA |
PIK3CA |
PTEN |
RAF-1 |
RET |
ROS1 |
SF3B1 |
SMAD4 |
SMO |
TP53 |
Healthcare providers should only order panels if each gene or test in the panel is medically necessary.